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Temporally Graded Retrograde Amnesia of Contextual Fear after Hippocampal Damage in Rats: Within-Subjects Examination
 

Summary: Temporally Graded Retrograde Amnesia of Contextual Fear after
Hippocampal Damage in Rats: Within-Subjects Examination
Stephan G. Anagnostaras,1 Stephen Maren,2 and Michael S. Fanselow1
1Department of Psychology and Brain Research Institute, University of California, Los Angeles, California 90095-1563,
and 2Department of Psychology and Neuroscience Program, University of Michigan, Ann Arbor, Michigan 48109
We have shown previously that electrolytic lesions of the dorsal
hippocampus (DH) produce a severe deficit in contextual fear if
made 1 d, but not 28 d, after fear conditioning (Kim and
Fanselow, 1992). As such, the hippocampus seems to play a
time-limited role in the consolidation of contextual fear condi-
tioning. Here, we examine retrograde amnesia of contextual
fear produced by DH lesions in a within-subjects design. Unlike
our previous reports, rats had both a remote and recent mem-
ory at the time of the lesion. Rats were given 10 tone­shock
pairings in one context (remote memory) and 10 tone­shock
pairings in a distinct context (with a different tone) 50 d later
(recent memory), followed by DH or sham lesions 1 d later.
Relative to controls, DH-lesioned rats exhibited no deficit in
remote contextual fear, but recent contextual fear memory was
severely impaired. They also did not exhibit deficits in tone

  

Source: Anagnostaras, Stephan - Neurosciences Program & Department of Psychology, University of California at San Diego

 

Collections: Biology and Medicine