Summary: Developmental Cell, Vol. 6, 511­523, April, 2004, Copyright 2004 by Cell Press
Centrosome Maturation and Duplication in C. elegans
Require the Coiled-Coil Protein SPD-2
phase and completes before mitosis so that two centro-
somes are available to form the poles of the bipolar
spindle. Duplication involves the splitting of a centriole
Catherine A. Kemp,1
Kevin R. Kopish,2
Peder Zipperlen,3
Julie Ahringer,3
and Kevin F. O'Connell1,
*
pair followed by the synthesis of a new centriole adja-1
Laboratory of Biochemistry and Genetics
cent to each preexisting centriole (Kuriyama and Borisy,National Institute of Diabetes and Digestive and
1981). The replicated centrosomes then migrate apartKidney Diseases
in preparation for spindle assembly. As cells progressNational Institutes of Health
toward mitosis, the size and microtubule-nucleating ca-Bethesda, Maryland 20892
pacity of the centrosome increase, a process termed2
Promega Corporation

Source: Ahringe, Julie - Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge

Collections: Biology and Medicine