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Proteasome-Mediated Proteolysis of Estrogen Receptor: A Novel

Summary: Proteasome-Mediated Proteolysis
of Estrogen Receptor: A Novel
Component in Autologous
Elaine T. Alarid, Natalie Bakopoulos, and Natalia Solodin
The Department of Physiology
University of Wisconsin-Madison
Madison, Wisconsin 53706
Regulation of estrogen receptor (ER) concentra-
tion is a key component in limiting estrogen re-
sponsiveness in target cells. Yet the mechanisms
governing ER concentration in the lactotrope cells
of the anterior pituitary, a major site of estrogen
action, are undetermined. In this study, we used a
lactotrope cell line, PR1, to explore regulation of
ER protein by estrogen. Estrogen treatment re-
sulted in an approximate 60% decrease in ER
steady state protein levels. Suprisingly, the decline
in ER protein was apparent within 1 h of estrogen
treatment and occurred in the absence of protein


Source: Alarid, Elaine T. - Molecular and Cellular Pharmacology Training Program & Department of Oncology,University of Wisconsin at Madison


Collections: Biology and Medicine