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Developmental Cell, Vol. 8, 689701, May, 2005, Copyright 2005 by Elsevier Inc. DOI 10.1016/j.devcel.2005.02.011 FGF Signal Interpretation Is Directed
 

Summary: Developmental Cell, Vol. 8, 689701, May, 2005, Copyright 2005 by Elsevier Inc. DOI 10.1016/j.devcel.2005.02.011
FGF Signal Interpretation Is Directed
by Sprouty and Spred Proteins
during Mesoderm Formation
Jeremy M. Sivak,1,3
Lars F. Petersen,1,2,3
FGFR during this process is the ras/MAPK pathway
(Schlessinger, 2000). Inhibition of any component ofand Enrique Amaya1,2,
*
this pathway subsequently blocks the expression of1
The Wellcome Trust/Cancer Research UK Gurdon
mesodermal markers (Gupta and Mayer, 1998; Mac-Institute
Nicol et al., 1993; Tang et al., 1995; Whitman and Mel-University of Cambridge
ton, 1992). FGF signaling has also been shown to di-Tennis Court Road Cambridge
rectly affect morphogenetic cell movements duringCB2 1QN
gastrulation (Ciruna et al., 1997; Yang et al., 2002). WeUnited Kingdom
have shown that this effect occurs through the FGFR2
Department of Zoology
via a mechanism that is distinct from the ras/MAPKUniversity of Cambridge
pathway (Nutt et al., 2001). Therefore, FGFR signalingDowning Site, Cambridge

  

Source: Amaya, Enrique - Healing Foundation Centre & Developmental Biology, Faculty of Life Sciences, University of Manchester

 

Collections: Biology and Medicine