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Summary: Research Focus
Kinesin-8 molecular motors: putting the brakes
on chromosome oscillations
Melissa K. Gardner1
, David J. Odde1
and Kerry Bloom2
1
Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA
2
Department of Biology, University of North Carolina, Chapel Hill, NC 27599-3280, USA
Recent studies suggest that the human Kinesin-8
molecular motor Kif18A has a role in chromosome
congression. Specifically, these studies find that Kif18A
promotes chromosome congression by attenuating
chromosome oscillation magnitudes. Together with
recent modeling work, in vitro studies, and the analysis
of in vivo yeast data, these reports reveal how Kinesin-8
molecular motors might control chromosome oscillation
amplitudes by spatially regulating the dynamic instabil-
ity of microtubule plus-ends within the mitotic spindle.
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