Home

About

Advanced Search

Browse by Discipline

Scientific Societies

E-print Alerts

Add E-prints

E-print Network
FAQHELPSITE MAPCONTACT US


  Advanced Search  

 
Research Focus Kinesin-8 molecular motors: putting the brakes
 

Summary: Research Focus
Kinesin-8 molecular motors: putting the brakes
on chromosome oscillations
Melissa K. Gardner1
, David J. Odde1
and Kerry Bloom2
1
Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA
2
Department of Biology, University of North Carolina, Chapel Hill, NC 27599-3280, USA
Recent studies suggest that the human Kinesin-8
molecular motor Kif18A has a role in chromosome
congression. Specifically, these studies find that Kif18A
promotes chromosome congression by attenuating
chromosome oscillation magnitudes. Together with
recent modeling work, in vitro studies, and the analysis
of in vivo yeast data, these reports reveal how Kinesin-8
molecular motors might control chromosome oscillation
amplitudes by spatially regulating the dynamic instabil-
ity of microtubule plus-ends within the mitotic spindle.

  

Source: Asbury, Chip - Department of Physiology and Biophysics, University of Washington at Seattle
Bloom, Kerry S.- Department of Biology, University of North Carolina at Chapel Hill

 

Collections: Biology and Medicine