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Acta Neuropathol (2008) 116:479489 DOI 10.1007/s00401-008-0434-7

Summary: Acta Neuropathol (2008) 116:479489
DOI 10.1007/s00401-008-0434-7
Selective reduction of Von Economo neuron number
in agenesis of the corpus callosum
Jason A. Kaufman Lynn K. Paul
Kebreten F. Manaye Andrea E. Granstedt
Patrick R. Hof Atiya Y. Hakeem John M. Allman
Received: 15 January 2008 / Revised: 10 September 2008 / Accepted: 11 September 2008 / Published online: 25 September 2008
Springer-Verlag 2008
Abstract Von Economo neurons (VENs) are large spin-
dle-shaped neurons localized to anterior cingulate cortex
(ACC) and fronto-insular cortex (FI). VENs appear late in
development in humans, are a recent phylogenetic special-
ization, and are selectively destroyed in frontotemporal
dementia, a disease which profoundly disrupts social
functioning and self-awareness. Agenesis of the corpus
callosum (AgCC) is a congenital disorder that can have
signiWcant eVects on social and emotional behaviors,


Source: Allman, John M. - Division of Biology, California Institute of Technology


Collections: Biology and Medicine