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BioMed Central Page 1 of 15

Summary: BioMed Central
Page 1 of 15
(page number not for citation purposes)
BMC Molecular Biology
Open AccessResearch article
Biased exonization of transposed elements in duplicated genes: A
lesson from the TIF-IA gene
Maayan Amit1, Noa Sela1, Hadas Keren1, Ze'ev Melamed1, Inna Muler1,2,3,
Noam Shomron4, Shai Izraeli1,2,3 and Gil Ast*1
Address: 1Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel-Aviv University, Ramat Aviv 69978, Israel,
2Chaim Sheba Cancer Research Center, Tel Hashomer, Israel, 3Pediatric Hemato-Oncology, Sheba Medical Center, Tel Hashomer, Israel and
4Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Email: Maayan Amit - maayana2@post.tau.ac.il; Noa Sela - noasela@post.tau.ac.il; Hadas Keren - hadasker@post.tau.ac.il;
Ze'ev Melamed - zeevmela@post.tau.ac.il; Inna Muler - imuler@yahoo.com; Noam Shomron - nshomron@mit.edu;
Shai Izraeli - Shai.Izraeli@sheba.health.gov.il; Gil Ast* - gilast@post.tau.ac.il
* Corresponding author
Background: Gene duplication and exonization of intronic transposed elements are two
mechanisms that enhance genomic diversity. We examined whether there is less selection against
exonization of transposed elements in duplicated genes than in single-copy genes.


Source: Ast, Gil - Department of Molecular Genetics and Biochemistry, Tel Aviv University


Collections: Biology and Medicine