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ROLE OF COLLAGEN IN THE TEMPERATURE DEPENDENCE OF ULTRASONIC BACKSCATTERROLE OF COLLAGEN IN THE TEMPERATURE DEPENDENCE OF ULTRASONIC BACKSCATTER Debomita Basu,
 

Summary: ROLE OF COLLAGEN IN THE TEMPERATURE DEPENDENCE OF ULTRASONIC BACKSCATTERROLE OF COLLAGEN IN THE TEMPERATURE DEPENDENCE OF ULTRASONIC BACKSCATTER
Debomita Basu,
R. Martin Arthur,
Jason W. Trobaugh
Debomita Basu,
R. Martin Arthur,
Jason W. Trobaugh
ABSTRACT
Purpose. The combination of hyperthermia with conventional chemotherapy or radiation has
proven to be beneficial in the treatment of cancer. A major limitation for hyperthermia
currently is the absence of adequate information about the temperature distribution in soft
tissue to guide thermal dosimetry. We predicted a monotonic change in ultrasound
backscattered energy using lipid and aqueous subwavelength scatterers [1]. Invitro
experiments with porcine and turkey tissue verified this prediction. Studies by others have
indicated that the echo pattern in ultrasonic images is determined largely by the content,
configuration, and distribution of collagen. To better understand the phenomena that cause
changes in backscattered energy (CBE), we have 1) refined our theoretical model to include
collagen and 2) examined the relationship between CBE and tissue structure in both simulated
and measured images.
Methods. CBE images were formed from simulated Bmode images [2]. Simulated images

  

Source: Arthur, R. Martin - Department of Electrical and Systems Engineering, Washington University in St. Louis

 

Collections: Biology and Medicine; Engineering