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Molecular Dissection of Psoriasis: Integrating Genetics and James T. Elder1,2

Summary: Molecular Dissection of Psoriasis: Integrating Genetics and
James T. Elder1,2
, Allen T. Bruce1,4
, Johann E. Gudjonsson1,4
, Andrew Johnston1,4
, Philip E. Stuart1
Trilokraj Tejasvi1
, John J. Voorhees1
, Gonc¸alo R. Abecasis3
and Rajan P. Nair1
Psoriasis is a common and debilitating disease of the
skin, nails, and joints, with an acknowledged but
complex genetic basis. Early genome-wide linkage
studies of psoriasis focused on segregation of micro-
satellite markers in families; however, the only locus
consistently identified resided in the major histocom-
patibility complex. Subsequently, several groups
mapped this locus to the vicinity of HLA-C, and two


Source: Abecasis, Goncalo - Department of Biostatistics, University of Michigan


Collections: Biology and Medicine; Mathematics