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Deficits in memory and motor performance in synaptotagmin IV mutant mice

Summary: Deficits in memory and motor performance in
synaptotagmin IV mutant mice
Gregory D. Ferguson*, Stephan G. Anagnostaras
, Alcino J. Silva§¶
, and Harvey R. Herschman*¶
Departments of *Biological Chemistry, Neurobiology, Psychiatry, §Psychology, and Pharmacology, and ¶Brain Research Institute and **Molecular Biology
Institute, University of California, Los Angeles, CA 90095
Communicated by Michael E. Phelps, University of California, Los Angeles, CA, March 9, 2000 (received for review November 20, 1999)
Synaptotagmin (Syt) IV is a synaptic vesicle protein. Syt IV expres-
sion is induced in the rat hippocampus after systemic kainic acid
treatment. To examine the functional role of this protein in vivo,
we derived Syt IV null [Syt IV( )] mutant mice. Studies with the
rotorod revealed that the Syt IV mutants have impaired motor
coordination, a result consistent with constitutive Syt IV expression
in the cerebellum. Because Syt IV is thought to modulate synaptic
function, we also have examined Syt IV mutant mice in learning
and memory tests. Our studies show that the Syt IV mutation
disrupts contextual fear conditioning, a learning task sensitive to
hippocampal and amygdala lesions. In contrast, cued fear condi-


Source: Anagnostaras, Stephan - Neurosciences Program & Department of Psychology, University of California at San Diego
Silva, Alcino - Department of Neurobiology, University of California at Los Angeles


Collections: Biology and Medicine