Summary: How Flies Time When They're Having Brunch
1Department of Neurobiology and Physiology, Northwestern University, 2205 Tech Drive, #2-160, Evanston, IL 60201, USA
Coordinated timing of circadian clocks is thought to be crucial for optimal energy homeostasis. In this issue
of Cell Metabolism, Xu et al. (2008) explore the fruit fly as a model system to examine the links between
clocks, feeding, and metabolism.
It is not surprising that life on earth has
evolved circadian clocks to anticipate
changes in our 24 hr environment. The
discovery of the core mechanisms of
circadian clocks has yielded unexpected
insights into their function in a range of
homeostatically regulated processes.
Perhaps nowhere is this more evident
than in the study of energy homeostasis.
These clocks regulate a host of metabolic
parameters as well as genes involved in
carbohydrate and lipid metabolism (Koh-