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IEEE JOURNAL OF SELECTED TOPICS IN SIGNAL PROCESSING, VOL. 2, NO. 6, DECEMBER 2008 907 SPHARM-Based Spatial fMRI Characterization With
 

Summary: IEEE JOURNAL OF SELECTED TOPICS IN SIGNAL PROCESSING, VOL. 2, NO. 6, DECEMBER 2008 907
SPHARM-Based Spatial fMRI Characterization With
Intersubject Anatomical Variability Reduction
Ashish Uthama, Rafeef Abugharbieh, Samantha J. Palmer, Anthony Traboulsee, and Martin J. McKeown
Abstract--It has been recently shown that spatial patterns of
activation within regions of interest (ROIs) in functional mag-
netic resonance imaging (fMRI) data can be used as sensitive
markers of brain activation differences. In this paper, we propose
novel invariant features for characterizing such spatial activation
patterns based on spherical harmonic (SPHARM) data represen-
tations. The proposed three dimensional (3-D) spatial features are
novel in that; first, they provide a unique representation of any
ROI's functional data; second, they simultaneously account for
inherent inter-subject anatomical variability that may influence
any spatial characterization; third, they are invariant to similarity
transformations and hence allow for direct comparisons between
ROIs without any requirement for normalization to an atlas.
We present quantitative validation demonstrating our method's
improved sensitivity in performing group analysis when com-
pared to traditional spatial normalization using synthetic data

  

Source: Abugharbieh, Rafeef - Department of Electrical and Computer Engineering, University of British Columbia

 

Collections: Biology and Medicine; Computer Technologies and Information Sciences