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Error Tolerance of DNA Self-Assembly by Monomer Concentration Control

Summary: Error Tolerance of DNA Self-Assembly by
Monomer Concentration Control
Byunghyun Jang, Yong-Bin Kim and Fabrizio Lombardi
Department of Electrical and Computer Engineering
Northeastern University
Boston, MA 02115
Email: {bjang, ybk, lombardi}@ece.neu.edu
Abstract-- This paper proposes the control of monomer con-
centration as a novel improvement of the kinetic Tile Assem-
bly Model (kTAM) to reduce the error rate in DNA self-
assembly. Tolerance to errors in this process is very important
for manufacturing highly dense ICs; the proposed technique
significantly decreases error rates (i.e. it increases error tolerance)
by controlling the concentration of monomers. A stochastic
analysis based on a new state model is presented. Error rates
reductions of at least 10% are found by evaluating the proposed
scheme comparing to a scheme with constant concentration. One
of the significant advantages of the proposed scheme is that it
doesn't entail an overhead such as increase in size and a slow
growth, while still achieving a significant reduction in error rate.


Source: Ayers, Joseph - Marine Science Center & Department of Biology, Northeastern University


Collections: Engineering