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Signaling at the Slit Diaphragm THOMAS BENZING
 

Summary: Signaling at the Slit Diaphragm
THOMAS BENZING
Renal Division, University Hospital Freiburg, Freiburg, Germany
Diseases of the glomerular filter of the kidney are a leading
cause of end-stage renal failure. Recent studies have empha-
sized the critical role of the slit diaphragm of podocytes for the
size-selective filtration barrier of the kidney and revealed novel
aspects of the mechanisms that lead to proteinuria, in both
inherited and acquired diseases (14). Several critical struc-
tural protein components of the slit diaphragm have been
identified. Recently, it has been speculated that these slit dia-
phragm proteins, in addition to their structural functions, par-
ticipate in common signaling pathways. This review focuses on
what is known about signaling at the slit diaphragm. It provides
a snapshot of our current understanding of the signaling prop-
erties of slit diaphragm proteins and projects a framework for
further studies necessary to delineate the function and dynam-
ics of the slit diaphragm protein complex and the pathogenesis
of nephrotic syndrome.
Ultrafiltration of plasma in the renal glomeruli is a major

  

Source: Akabas, Myles - Department of Physiology and Biophysics, Albert Einstein College of Medicine, Yeshiva University

 

Collections: Biology and Medicine