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The physiological and molecular regulation of lipoprotein assembly and Daniel A. Blasiole,a

Summary: The physiological and molecular regulation of lipoprotein assembly and
Daniel A. Blasiole,a
Roger A. Davisb
and Alan D. Attie*a
Received 16th January 2007, Accepted 30th May 2007
First published as an Advance Article on the web 16th July 2007
DOI: 10.1039/b700706j
Triglycerides are insoluble in water and yet are transported at milligram per millilitre
concentrations in the bloodstream. This is made possible by the ability of the liver and intestine to
assemble lipid­protein emulsions (i.e. lipoproteins), which transport hydrophobic molecules. The
assembly of triglyceride-rich lipoproteins requires the coordination of protein and lipid synthesis,
which occurs on the cytoplasmic surface of the endoplasmic reticulum (ER), and their concerted
assembly and translocation into the luminal ER secretory pathway as nascent lipoprotein
particles. The availability of lipid substrate for triglyceride production and the machinery for
lipoprotein assembly are highly sensitive to nutritional, hormonal, and genetic modulation.
Disorders in lipid metabolism or an imbalance between lipogenesis and lipoprotein assembly can
lead to hyperlipidemia and/or hepatic steatosis. We selectively review recently-identified
machinery, such as transcription factors and nuclear hormone receptors, which provide new clues
to the regulation of lipoprotein secretion.


Source: Attie, Alan D. - Department of Biochemistry, University of Wisconsin at Madison


Collections: Biology and Medicine