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BioMed Central Page 1 of 15

Summary: BioMed Central
Page 1 of 15
(page number not for citation purposes)
Biology Direct
Open AccessResearch
The immune-body cytokine network defines a social architecture of
cell interactions
Ziv Frankenstein1,2, Uri Alon2 and Irun R Cohen*1
Address: 1Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel and 2Department of Molecular Cell Biology and
Department of Physics of Complex Systems, The Weizmann Institute of Science, Rehovot 76100, Israel
Email: Ziv Frankenstein - ziv.frankenstein@weizmann.ac.il; Uri Alon - uri.alon@weizmann.ac.il; Irun R Cohen* - irun.cohen@weizmann.ac.il
* Corresponding author
Background: Three networks of intercellular communication can be associated with cytokine
secretion; one limited to cells of the immune system (immune cells), one limited to parenchymal
cells of organs and tissues (body cells), and one involving interactions between immune and body
cells (immune-body interface). These cytokine connections determine the inflammatory response
to injury and subsequent healing as well as the biologic consequences of the adaptive immune
response to antigens. We informatically probed the cytokine database to uncover the underlying
network architecture of the three networks.


Source: Alon, Uri - Departments of Molecular Cell Biology & Physics of Complex Systems, Weizmann Institute of Science


Collections: Biology and Medicine