Home

About

Advanced Search

Browse by Discipline

Scientific Societies

E-print Alerts

Add E-prints

E-print Network
FAQHELPSITE MAPCONTACT US


  Advanced Search  

 
2008LANDESBIOSCIENCE.DONOTDISTRIBUTE. RNA Biology 2008; Vol. 5 Issue
 

Summary: 
2008LANDESBIOSCIENCE.DONOTDISTRIBUTE.
RNA Biology 2008; Vol. 5 Issue
Thismanuscripthasbeenpublishedonline,priortoprinting.Oncetheissueiscompleteandpagenumbershavebeenassigned,thecitationwillchangeaccordingly.
Splicing is a molecular mechanism, by which introns are
removed from an mRNA precursor and exons are ligated to form a
mature mRNA. Mutations that cause defects in the splicing mecha-
nism are known to be responsible for many diseases, including
cystic fibrosis and familial dysautonomia. If mutations that cause
defects in splicing are responsible for such severe deleterious pheno-
typic differences, it is possible that mutations in splicing are also
responsible for mildly deleterious phenotypic differences. Although
deleterious mutations are rapidly eliminated from the population
by purifying selection, the selection against mild deleterious effects
is not as strong. Since mildly deleterious mutations have a chance
of surviving natural selection, we might be mistakenly referring to
these mutations as neutral variation between individuals. Splicing
has also been shown to be seriously affected in cancer. Examination
of cancerous tissues revealed alterations in expression levels of
genes involved in mRNA processing and also a slight reduction in

  

Source: Ast, Gil - Department of Molecular Genetics and Biochemistry, Tel Aviv University

 

Collections: Biology and Medicine