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Brain Functional and Anatomical Changes in Chronic Prostatitis/Chronic Pelvic Pain Syndrome
 

Summary: Brain Functional and Anatomical Changes in Chronic
Prostatitis/Chronic Pelvic Pain Syndrome
Melissa A. Farmer, Mona L. Chanda, Elle L. Parks, Marwan N. Baliki,
A. Vania Apkarian,*, and Anthony J. Schaeffer,,
From the Departments of Physiology (MAF, MLC, ELP, MNB, AVA), Urology (AJS), Anesthesia (AVA) and Surgery (AVA),
Feinberg School of Medicine, Northwestern University, Chicago, Illinois
Purpose: Research into the pathophysiology of chronic prostatitis/chronic pelvic
pain syndrome has primarily focused on markers of peripheral dysfunction. We
present the first neuroimaging investigation to our knowledge to characterize
brain function and anatomy in chronic prostatitis/chronic pelvic pain syndrome.
Materials and Methods: We collected data from 19 male patients with chronic
prostatitis/chronic pelvic pain syndrome, and 16 healthy age and gender matched
controls. Functional magnetic resonance imaging data were obtained from 14
patients with chronic prostatitis/chronic pelvic pain syndrome as they rated
spontaneous pain inside the scanner. Group differences (16 patients per group) in
gray matter total volume and regional density were evaluated using voxel-based
morphometry, and white matter integrity was studied with diffusion tensor
imaging to measure fractional anisotropy. Functional and anatomical imaging
outcomes were correlated with the clinical characteristics of chronic prostatitis/
chronic pelvic pain syndrome.

  

Source: Apkarian, A. Vania - Department of Physiology, Northwestern University

 

Collections: Biology and Medicine