Summary: JOURNAL OF BACTERIOLOGY, Nov. 2007, p. 8165­8178 Vol. 189, No. 22
0021-9193/07/$08.00 0 doi:10.1128/JB.00586-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.
BifA, a Cyclic-Di-GMP Phosphodiesterase, Inversely Regulates Biofilm
Formation and Swarming Motility by Pseudomonas aeruginosa PA14
Sherry L. Kuchma,1
Kimberly M. Brothers,1
Judith H. Merritt,1
Nicole T. Liberati,2,3
Frederick M. Ausubel,2,3
and George A. O'Toole1
*
Department of Microbiology and Immunology, Dartmouth Medical School, Room 505, Vail Building, North College Street,
Hanover, New Hampshire 037551
; Department of Genetics, Harvard Medical School, Boston, Massachusetts 021142
;
and Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 021143
Received 16 April 2007/Accepted 11 June 2007
The intracellular signaling molecule, cyclic-di-GMP (c-di-GMP), has been shown to influence bacterial
behaviors, including motility and biofilm formation. We report the identification and characterization of

Source: Ausubel, Frederick M. - Department of Genetics, Harvard University

Collections: Biology and Medicine