Home

About

Advanced Search

Browse by Discipline

Scientific Societies

E-print Alerts

Add E-prints

E-print Network
FAQHELPSITE MAPCONTACT US


  Advanced Search  

 
Copyright 2002 by Lipid Research, Inc. 1610 Journal of Lipid Research Volume 43, 2002 This article is available online at http://www.jlr.org
 

Summary: Copyright © 2002 by Lipid Research, Inc.
1610 Journal of Lipid Research Volume 43, 2002 This article is available online at http://www.jlr.org
Identification and functional analysis of a naturally
occurring E89K mutation in the ABCA1 gene of the
WHAM chicken
Alan D. Attie,1,* Yannick Hamon, Angela R. Brooks-Wilson,§ Mark P. Gray-Keller,*
Marcia L. E. MacDonald,§ Veronique Rigot, Angie Tebon,* Lin-Hua Zhang,§ Jacob D. Mulligan,*
Roshni R. Singaraja,§§ J. James Bitgood,** Mark E. Cook,** John J. P. Kastelein,
Giovanna Chimini, and Michael R. Hayden§§
Departments of Biochemistry,* University of Wisconsin-Madison, Madison, WI 53706; Department of
Biochemistry, Centre d'Immunologie de Marseille Luminy, 13288 CEDEX 09, France; Xenon Genetics Inc.,§
Vancouver, BC, V5G 4W8, Canada; Department of Animal Sciences,** University of Wisconsin-Madison,
Madison, WI 53706; Department of Vascular Medicine, Academic Medical Centre, Amsterdam, The
Netherlands; and Department of Medical Genetics,§§ Centre for Molecular Medicine and Therapeutics and
Department of Medical Genetics, Children's and Women's Hospital, University of British Columbia,
Vancouver, BC V5Z 4H5, Canada
Abstract The Wisconsin hypoalpha mutant (WHAM)
chicken has a 90% reduction in plasma HDL due to hy-
percatabolism by the kidney of lipid-poor apoA-I. The WHAM
chickens have a recessive white skin phenotype caused by a

  

Source: Attie, Alan D. - Department of Biochemistry, University of Wisconsin at Madison

 

Collections: Biology and Medicine