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Cell packing influences planar cell polarity signaling , Keith Amonlirdvimanb,1

Summary: Cell packing influences planar cell polarity signaling
Dali Maa,1
, Keith Amonlirdvimanb,1
, Robin L. Raffardb,1
, Alessandro Abateb,c
, Claire J. Tomlinb,c
, and Jeffrey D. Axelroda,2
aDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305-5324; bDepartment of Electrical Engineering and Computer Sciences,
University of California, Berkeley, CA 94720; and cDepartment of Aeronautics and Astronautics, Stanford University, Stanford, CA 94305-4035
Communicated by A. Dale Kaiser, Stanford University School of Medicine, Stanford, CA, September 23, 2008 (received for review August 2, 2008)
Some epithelial cells display asymmetry along an axis orthogonal
to the apical-basal axis, referred to as planar cell polarity (PCP). A
Frizzled-mediated feedback loop coordinates PCP between neigh-
boring cells, and the cadherin Fat transduces a global directional
cue that orients PCP with respect to the tissue axes. The feedback
loop can propagate polarity across clones of cells that lack the
global directional signal, although this polarity propagation is
error prone. Here, we show that, in the Drosophila wing, a
combination of cell geometry and nonautonomous signaling at
clone boundaries determines the correct or incorrect polarity prop-


Source: Abate, Alessandro - Faculty of Mechanical, Maritime and Materials Engineering, Technische Universiteit Delft


Collections: Engineering