Home

About

Advanced Search

Browse by Discipline

Scientific Societies

E-print Alerts

Add E-prints

E-print Network
FAQHELPSITE MAPCONTACT US


  Advanced Search  

 
Proc. Natl. Acad. Sci. USA Vol. 95, pp. 1429014295, November 1998
 

Summary: Proc. Natl. Acad. Sci. USA
Vol. 95, pp. 14290­14295, November 1998
Genetics
Tsetse thrombin inhibitor: Bloodmeal-induced expression of an
anticoagulant in salivary glands and gut tissue of Glossina
morsitans morsitans
(serine protease inhibitor trypanosomiasis)
MICHAEL CAPPELLO*, SONG LI§, XIAOAI CHEN§, CHANG-BEN LI§, LISA HARRISON*,
SUKANYA NARASHIMHAN, CHARLES B. BEARD¶, AND SERAP AKSOY
Department of Epidemiology and Public Health, Section of Vector Biology, and *Department of Pediatrics, Yale University School of Medicine, New Haven, CT
06510; §Institute of Genetics, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, 200433, People's Republic of China; and ¶Centers for
Disease Control and Prevention, Division of Parasitic Diseases, Mail Stop F-12, Atlanta, GA 30341
Communicated by Jiazhen Tan, Fudan University, Shanghai, People's Republic of China, September 29, 1998 (received for review June 25, 1998)
ABSTRACT The tsetse thrombin inhibitor, a potent and
specific low molecular mass (3,530 Da) anticoagulant peptide,
was purified previously from salivary gland extracts of Glossina
morsitans morsitans (Diptera: Glossinidae). A 303-bp coding
sequence corresponding to the inhibitor has now been isolated
from a tsetse salivary gland cDNA library by using degenerate
oligonucleotide probes. The full-length cDNA contains a 26-bp

  

Source: Aksoy, Serap - School of Public Health, Yale University

 

Collections: Biology and Medicine