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Transcriptome analysis and molecular signature of human retinal pigment epithelium

Summary: Transcriptome analysis and molecular signature
of human retinal pigment epithelium
N.V. Strunnikova1,4, A. Maminishkis2,4, J.J. Barb5, F. Wang2,4, C. Zhi2,4, Y. Sergeev1,4, W. Chen6,
A.O. Edwards7, D. Stambolian8, G. Abecasis6, A. Swaroop3,4, P.J. Munson5 and S.S. Miller2,4,
Ophthalmic Genetics & Visual Function Branch, 2
Section of Epithelial and Retinal Physiology and Disease,
Neurobiology-Neurodegeneration & Repair Laboratory and 4
National Eye Institute/NIH, Bethesda, MD, USA,
Mathematical and Statistical Computing Laboratory, Center for Information Technology/NIH, Bethesda, MD, USA,
Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA, 7
Institute for Molecular Biology,
University of Oregon, Eugene, OR, USA and 8
Ophthalmology, University of Pennsylvania, Philadelphia, PA, USA
Received December 14, 2009; Revised March 3, 2010; Accepted March 30, 2010
Retinal pigment epithelium (RPE) is a polarized cell layer critical for photoreceptor function and survival. The
unique physiology and relationship to the photoreceptors make the RPE a critical determinant of human


Source: Abecasis, Goncalo - Department of Biostatistics, University of Michigan


Collections: Biology and Medicine; Mathematics