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European Journal of Neuroscience, Vol. 9, pp. 396-409, 1997 0 European Neuroscience Association Differential Effects of Acetylcholine on Neuronal Activity
 

Summary: European Journal of Neuroscience, Vol. 9, pp. 396-409, 1997 0 European Neuroscience Association
Differential Effects of Acetylcholine on Neuronal Activity
and Interactions in the Auditory Cortex of the Guinea-pig
Daniel E. Shulzl, Shuki Cohen, Sebastian Haidarliu and Ehud Ahissar
Departmentof Neurobiology,Weizmann Instituteof Science, 76100 Rehovot, Israel
'Equipe Cognisciences, lnstitut A. Fessard,CNRS, 91190 Gif sur Yvette, France
Keywords: acetylcholinesterase,autocorrelation,carbachol, cross-correlation,functional connectivity
Abstract
During normal brain operations, cortical neurons are subjectedto continuouscholinergic modulations. In vitm
studies have indicated that, in addition to affecting general cellular excitability, acetylcholine also modulates
synaptic transmission. Whether these cholinergic mechanisms lead to a modulation of functional connectivity
in vivo is not yet known. Herein,the effects were studied of an iontophoreticapplicationof acetylcholineand of
the muscarinic agonist, carbachol, on the ongoing activity and co-activity of neurons simultaneously recorded in
the auditory cortex of the anaesthetizedguinea-pig. lontophoresisof cholinergic agonists mainly affected the
spontaneous firing rates of auditory neurons, affected autocorrelationsless (in most cases their central peak
areas were reduced),and rarely affected cross-correlations.These findings are consistent with cholinergic
agonists primarily affecting the excitability of cortical neurons rather than the strength of cortical connections.
However, when changes of cross-correlationsoccurred, they were usually not correlatedwith concomitant
changes in average firing rates nor with changes in autocorrelations,which suggests a secondary cholinergic
effect on specific cortico-corticalor thalamo-corticalconnections,

  

Source: Ahissar, Ehud - Department of Neurobiology, Weizmann Institute of Science

 

Collections: Biology and Medicine