Home

About

Advanced Search

Browse by Discipline

Scientific Societies

E-print Alerts

Add E-prints

E-print Network
FAQHELPSITE MAPCONTACT US


  Advanced Search  

 
1222 IEEE TRANSACTIONS ON MEDICAL IMAGING, VOL. 21, NO. 10, OCTOBER 2002 Tracking Leukocytes In Vivo With Shape and Size
 

Summary: 1222 IEEE TRANSACTIONS ON MEDICAL IMAGING, VOL. 21, NO. 10, OCTOBER 2002
Tracking Leukocytes In Vivo With Shape and Size
Constrained Active Contours
Nilanjan Ray, Student Member, IEEE, Scott T. Acton3, Senior Member, IEEE, and Klaus Ley
Abstract--Inflammatory disease is initiated by leukocytes (white
blood cells) rolling along the inner surface lining of small blood ves-
sels called postcapillary venules. Studying the number and velocity
of rolling leukocytes is essential to understanding and successfully
treating inflammatory diseases. Potential inhibitors of leukocyte
recruitment can be screened by leukocyte rolling assays and suc-
cessful inhibitors validated by intravital microscopy. In this paper,
we present an active contour or snake-based technique to automat-
ically track the movement of the leukocytes. The novelty of the pro-
posed method lies in the energy functional that constrains the shape
and size of the active contour. This paper introduces a significant
enhancement over existing gradient-based snakes in the form of a
modified gradient vector flow. Using the gradient vector flow, we
can track leukocytes rolling at high speeds that are not amenable
to tracking with the existing edge-based techniques. We also pro-
pose a new energy-based implicit sampling method of the points

  

Source: Acton, Scott - Department of Electrical and Computer Engineering, University of Virginia
Ray, Nilanjan - Department of Computing Science, University of Alberta

 

Collections: Computer Technologies and Information Sciences; Engineering