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JOURNAL OF N~~IKOPHYSIO~~O~;Y Vol. 73, No. 4, April 1995. /`v.itztd irr U.S.A.
 

Summary: JOURNAL OF N~~IKOPHYSIO~~O~;Y
Vol. 73, No. 4, April 1995. /`v.itztd irr U.S.A.
RAPID PUBLICATION
Lesion of the Nodulus and Ventral Uvula Abolish Steady-State
Off-Vertical Axis Otolith Response
DORA E. ANGELAKI AND BERNHARD J. M. HESS
Department of Sur-gery (Otolaryngology), University of Mississippi Medical Center, Jackson, Mississippi 39216-4505;
and Department qf Neurology, University Hospital Zurich, CH-8091, Switzerland
SUMMARY AND CONCLUSIONS
I. During rotations that dynamically activate utricular and saccu-
lar primary afferents, the otolith system centrally detects the veloc-
ity and direction of rotation of the head in space. This property is
experimentally manifested as a steady-state compensatory nystag-
mus during constant velocity off-vertical axis rotations. The com-
putational, physiological, and anatomic details of this response
remain presently unknown. Here we report that surgical inactiva-
tion of the cerebellar nodulus and ventral uvula abolished the ability
of the otolith system to generate steady-state nystagmus during
constant velocity rotation and to improve the dynamics of the
vestibuloocular reflex (VOR) during low-frequency sinusoidal os-

  

Source: Angelaki, Dora - Department of Anatomy and Neurobiology, Washington University in St. Louis

 

Collections: Biology and Medicine