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Fax +41 61 306 12 34 E-Mail karger@karger.ch

Summary: Fax +41 61 306 12 34
E-Mail karger@karger.ch
Original Paper
Hum Hered 2005;59:118­124
DOI: 10.1159/000085226
Linkage Disequilibrium: Ancient History
Drives the New Genetics
Gonçalo R. Abecasis Debashis Ghosh Thomas E. Nichols
Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Mich., USA
freys et al., 2001]. Recently, studies of genetic variation
an abundant class of DNA variants that can be cheaply
genotyped in very large numbers ­ the most recent ver-
sion of dbSNP [Sachidanandam et al., 2001] includes
about 10 million such polymorphisms, and it is likely that
many more exist [Carlson et al., 2003].
Like other genetic polymorphisms, these SNPs are not
independent, but exhibit complex relationships. For most
of them, a single mutation event in the distant past re-


Source: Abecasis, Goncalo - Department of Biostatistics, University of Michigan


Collections: Biology and Medicine; Mathematics