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Consequences of hippocampal damage across the autobiographical memory network in left

Summary: Consequences of hippocampal damage across
the autobiographical memory network in left
temporal lobe epilepsy
Donna Rose Addis,1,2,3
Morris Moscovitch2,3
and Mary Pat McAndrews1,2
Toronto Western Research Institute, 2
Department of Psychology, University of Toronto and 3
Rotman Research Institute,
Baycrest Centre for Geriatric Care, Toronto, ON, Canada
Correspondence to: Mary Pat McAndrews, Neuropsychology Clinic, 4F-409 Toronto Western Hospital, 399 Bathurst St.,
Toronto, ON, Canada M5T 2S8.
E-mail: mcandrws@uhnres.utoronto.ca
Lesion and neuroimaging evidence suggests the hippocampus (HC) is a crucial node in the neural network sup-
porting autobiographical memory (AM) retrieval, and thus focal damage to the HC may have functional con-
sequences for structures throughout the network.Using fMRI, we examined the impact of hippocampal damage
on the engagement and connectivity of the AM network in 11 patients with left temporal lobe epilepsy (mean
age of onset of seizures, 24 years) with significant left hippocampal atrophy and a mild AM deficit. All investiga-
tions were completed pre-surgically.The fMRI paradigm comprised three conditions: (i) retrieving specific AMs


Source: Addis, Donna Rose - Department of Psychology, University of Auckland


Collections: Biology and Medicine