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Simulating In Vivo Background Activity in a Slice with the Dynamic Clamp

Summary: Simulating In Vivo Background Activity in a Slice
with the Dynamic Clamp
Frances Chance
Department of Neurobiology and Behavior
University of California, Irvine
Irvine, CA 92697 and
L. F. Abbott
Center for Neuroscience
Department of Physiology and Cellular Biophysics
Columbia University College of Physicians and Surgeons
New York NY 10032-2695 USA
Neurons in vivo receive a large amount of internally generated "background" activity in
addition to synaptic input directly driven by an external stimulus. Stimulus-driven and
background synaptic inputs interact, through the nonlinearities of neuronal integration, in
interesting ways. The dynamic clamp can be used in vitro to duplicate background input,
allowing the experimenter to take advantage of the accessibility of neurons in vitro while
still studying them under in vivo conditions. In this chapter we discuss some results from
experiments in which a neuron is driven by current injection that simulates a stimulus-
driven input as well as dynamic-clamp-generated background activity. One of the effects


Source: Abbott, Laurence - Center for Neurobiology and Behavior & Department of Physiology and Cellular Biophysics, Columbia University


Collections: Biology and Medicine