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The Evolution of Gene Regulation Underlies a Morphological Difference

Summary: The Evolution of Gene Regulation
Underlies a Morphological Difference
between Two Drosophila Sister Species
Sangyun Jeong,1 Mark Rebeiz,1 Peter Andolfatto,2 Thomas Werner,1 John True,3 and Sean B. Carroll1,*
1Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, 1525 Linden Drive, Madison, WI 53706, USA
2Section of Ecology, Behavior and Evolution, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA
3Department of Ecology and Evolution, Stony Brook University, Stony Brook, NY 11794, USA
*Correspondence: sbcarrol@wisc.edu
DOI 10.1016/j.cell.2008.01.014
Understanding the mechanisms underlying the mor-
phological divergence of species is one of the central
goals of evolutionary biology. Here, we analyze the
genetic and molecular bases of the divergence of
body pigmentation patterns between Drosophila
yakuba and its sister species Drosophila santomea.
We found that loss of pigmentation in D. santomea
involved the selective loss of expression of the tan
and yellow pigmentation genes. We demonstrate
that tan gene expression was eliminated through


Source: Andolfatto, Peter - Department of Ecology and Evolutionary Biology, Princeton University


Collections: Biology and Medicine