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Intensity of Schistosoma Mansoni, Hepatitis B, Age, and Sex Predict Levels of Hepatic Periportal Thickening/Fibrosis (PPT/F): A Large-Scale Community-Based Study
 

Summary: Intensity of Schistosoma Mansoni, Hepatitis B, Age, and Sex Predict Levels of Hepatic
Periportal Thickening/Fibrosis (PPT/F): A Large-Scale Community-Based Study
in Ethiopia
Nega Berhe,* Bjørn Myrvang, and Svein G. Gundersen
Ullevål University Hospital, Department of Infectious Diseases, Centre for Imported and Tropical Diseases, Oslo, Norway; Aklilu
Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia; Institute for International Health, University of
Oslo, Oslo, Norway; Sorlandet Hospital HF and Agder University College, Kristiansand, Norway
Abstract. To elucidate determinants of morbidity in schistosomiasis mansoni, a community-based study was under-
taken involving 2,451 subjects (mean age, 18.8 ± 15.3 [SD] years) from four endemic sites in Ethiopia. Overall prevalence
of infection was 65.9%, reported blood in stools was 35.8%, and schistosomal periportal thickening/fibrosis (PPT/F) was
4.6%. Similarly, 43.2% were positive for at least one marker of hepatitis B virus (HBV), 5.3% were HBsAg positive, and
1.3% were anti-hepatitis C virus (HCV) positive. Prevalence of PPT/F increased significantly with increasing community
prevalence and intensity of S. mansoni infection. In a multiple logistic regression analysis, intensity of egg excretion,
markers of HBV infection, age, and male sex were significantly associated with PPT/F, whereas co-infection with other
intestinal helminths was associated with lower odds for PPT/F. HCV was not associated with S. mansoni infection or with
schistosomal PPT/F. In conclusion, integrated helminth control targeting school-aged children, who have the highest
burden infection, should be used to substantially reduce the risk of periportal fibrosis.
INTRODUCTION
Among parasitic infections, schistosomiasis is only second
to malaria in terms of public health importance, with > 200

  

Source: Arnold, Jonathan - Nanoscale Science and Engineering Center & Department of Genetics, University of Georgia

 

Collections: Biotechnology