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Molecular mechanisms of cocaine reward: Combined dopamine and serotonin transporter knockouts
 

Summary: Molecular mechanisms of cocaine reward: Combined
dopamine and serotonin transporter knockouts
eliminate cocaine place preference
Ichiro Sora*, F. Scott Hall*, Anne M. Andrews
, Masanari Itokawa*, Xiao-Fei Li*, Hong-Bing Wei*, Christine Wichems
,
Klaus-Peter Lesch§
, Dennis L. Murphy
, and George R. Uhl*¶
*Molecular Neurobiology, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, Baltimore, MD 21224; Laboratory
of Clinical Science, National Institute of Mental Health-Intramural Research Program, National Institutes of Health, Bethesda, MD 20892-1264;
Department of Chemistry, Pennsylvania State University, PA 16802; and §Department of Psychiatry, University of Wuš rzburg,
Wuš rzburg 97080, Germany
Edited by Solomon H. Snyder, Johns Hopkins University School of Medicine, Baltimore, MD, and approved February 28, 2001 (received for review January 24, 2001)
Cocaine blocks uptake by neuronal plasma membrane transporters
for dopamine (DAT), serotonin (SERT), and norepinephrine (NET).
Cocaine reward reinforcement has been linked to actions at DAT or
to blockade of SERT. However, knockouts of neither DAT, SERT, or
NET reduce cocaine reward reinforcement, leaving substantial un-
certainty about cocaine's molecular mechanisms for reward. Conceiv-

  

Source: Andrews, Anne M. - Huck Institutes of the Life Sciences, Pennsylvania State University

 

Collections: Biology and Medicine