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Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2
 

Summary: Inducible costimulator is required for type 2 antibody
isotype switching but not T helper cell type 2
responses in chronic nematode infection
P'ng Loke*, Xingxing Zang
, Lisa Hsuan
, Rebecca Waitz
, Richard M. Locksley§
, Judith E. Allen¶
, and James P. Allison
Departments of *Pathology and §Medicine and Microbiology Immunology, University of California, San Francisco, CA 94143; Howard Hughes
Medical Institute, Memorial Sloan-Kettering Cancer Center, Immunology Program, New York, NY 10021; University of California, Davis, CA 95616;
and ¶Institute of Cell, Animal, and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
Contributed by James P. Allison, May 19, 2005
Inducible costimulator (ICOS) has been suggested to perform an
important role in T helper cell type 2 (Th2) responses, germinal
center formation, and isotype switching. The role of ICOS in chronic
Th2 responses was studied in a nematode model with the filarial
parasite, Brugia malayi. Contrary to expectations, we did not
observe a significant defect in IL-4-producing Th2 cells in ICOS
mice or in eosinophil recruitment. We also found that ICOS was not

  

Source: Allen, Judith - School of Biological Sciences, University of Edinburgh

 

Collections: Biology and Medicine