Home

About

Advanced Search

Browse by Discipline

Scientific Societies

E-print Alerts

Add E-prints

E-print Network
FAQHELPSITE MAPCONTACT US


  Advanced Search  

 
A Tandem One-Pot, Microwave-Assisted Synthesis of Regiochemically Differentiated 1,2,4,5-Tetrahydro-1,4-Benzodiazepin-3-ones
 

Summary: A Tandem One-Pot, Microwave-Assisted Synthesis of Regiochemically Differentiated
1,2,4,5-Tetrahydro-1,4-Benzodiazepin-3-ones
Ravindra A. De Silva, Soumava Santra and Peter R. Andreana*
Department of Chemistry,
Wayne State University,
5101 Cass Ave,
Detroit, MI 48202
*pra@chem.wayne.edu
Supporting Information
Materials and Methods: All reagents were purchased from Aldrich unless otherwise mentioned. 2-
nitrobenzylamine was obtained from 2-nitrobenzylamine hydrochloride. 6-nitroveratraldehyde and 4-
aminoacetophenone were purchased from Alfa Aesar. Allyl amine was purchased from Acros.
Microwave reactions were conducted in a capped vial using a CEM Discover System. All reactions
were monitored using thin layer chromatography on 0.25 mm Dynamic Adsorbents, L.L.C. precoated
silica gel (particle size 0.03-0.07 mm, catalog no. 84111, lot # LA2006). Column chromatography was
performed using Whatman Purasil 60 (230-400 mesh ASTM) silica gel. Yields refer to
chromatographically and spectroscopically pure compounds. Diastereomeric ratios were determined
from 1
H NMR spectra and LC-MS. Proton and carbon-13 NMR spectra were recorded on Varian
Mercury 400, and Varian 500 Direct Drive System spectrometers. The residual CDCl3 singlet at 7.26

  

Source: Andreana, Peter R. - Department of Chemistry, Wayne State University

 

Collections: Chemistry