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Journal of Neurochemistry, 2001, 77, 292303 Aging alters the multichemical networking prole of the human
 

Summary: Journal of Neurochemistry, 2001, 77, 292±303
Aging alters the multichemical networking pro®le of the human
brain: an in vivo 1
H-MRS study of young versus middle-aged
subjects
Igor D. Grachev,*,
²,
³Amar Swarnkar,³ Nikolaus M. Szeverenyi,²,
³ Tarakad S. Ramachandran§
and A. Vania Apkarian¶
Departments of *Neurosurgery, ²Neuroscience & Physiology, ³Radiology and §Neurology, SUNY Upstate Medical University,
New York, USA
Department of Physiology, Northwestern University Medical School, Chicago, Illinois, USA
Abstract
In our most recent study of normal aging, we found decreased
concentration of multiple chemicals in the brain of middle-
aged subjects, as compared with younger subjects using
in vivo proton magnetic resonance spectroscopy (1
H-MRS).
We hypothesized that these age-dependent differences in

  

Source: Apkarian, A. Vania - Department of Physiology, Northwestern University

 

Collections: Biology and Medicine