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ANTI-APOPTOTIC FACTOR z-Val-Ala-Asp-FLUOROMETHYLKETONE PROMOTES THE SURVIVAL OF COCHLEAR HAIR CELLS IN A
 

Summary: ANTI-APOPTOTIC FACTOR z-Val-Ala-Asp-FLUOROMETHYLKETONE
PROMOTES THE SURVIVAL OF COCHLEAR HAIR CELLS IN A
MOUSE MODEL FOR HUMAN DEAFNESS
O. ATAR AND K. B. AVRAHAM*
Department of Human Molecular Genetics and Biochemistry, Sackler
Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
Abstract--A major challenge in the inner ear research field is
to restore hearing loss of both non-genetic and genetic ori-
gin. A large effort is being made to protect hair cells from cell
death after exposure to noise or drugs that can cause hearing
loss. Our research focused on protecting hair cells from cell
death occurring in a genetic model for human deafness.
POU4F3 is a transcription factor associated with human hear-
ing impairment. Pou4f3 knockout mice (Pou4f3 /
) have no
cochlear hair cells, resulting in complete deafness. Although
the hair cells appear to form properly, they progressively
degenerate via apoptosis. In order to rescue the hair cells in
the knockout mice, we produced explant cultures from
mouse cochleae at an early embryonic stage and treated the

  

Source: Avraham, Karen - Department of Human Genetics and Molecular Medicine, Tel Aviv University

 

Collections: Biology and Medicine