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A role for lateral hypothalamic orexin neurons in reward seeking
 

Summary: A role for lateral hypothalamic orexin neurons in
reward seeking
Glenda C. Harris1
, Mathieu Wimmer1
& Gary Aston-Jones1
The lateral hypothalamus is a brain region historically implicated
in reward and motivation14
, but the identity of the neurotrans-
mitters involved are unknown. The orexins (or hypocretins) are
neuropeptides recently identified as neurotransmitters in lateral
hypothalamus neurons5,6
. Although knockout and transgenic
overexpression studies have implicated orexin neurons in arousal
and sleep7
, these cells also project to reward-associated brain
regions, including the nucleus accumbens and ventral tegmental
area8,9
. This indicates a possible role for these neurons in reward
function and motivation3,10
, consistent with previous studies

  

Source: Aston-Jones, Gary - Department of Neurosciences, Medical University of South Carolina

 

Collections: Biology and Medicine