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Testing the null hypothesis of the nonexistence of a preseizure state Ralph G. Andrzejak,1,
 

Summary: Testing the null hypothesis of the nonexistence of a preseizure state
Ralph G. Andrzejak,1,
* Florian Mormann,2,3
Thomas Kreuz,1,2
Christoph Rieke,2,3
Alexander Kraskov,1
Christian E. Elger,2
and Klaus Lehnertz2
1
John-von-Neumann Institute for Computing, Forschungszentrum Ju¨lich, 52425 Ju¨lich, Germany
2
Department of Epileptology, University of Bonn, Sigmund-Freud-Straße 25, 53105 Bonn, Germany
3
Helmholtz Institut fu¨r Strahlen- und Kernphysik, University of Bonn, Nußallee 14-16, 53115 Bonn, Germany
Received 16 June 2002; published 7 January 2003
A rapidly growing number of studies deals with the prediction of epileptic seizures. For this purpose, various
techniques derived from linear and nonlinear time series analysis have been applied to the electroencephalo-
gram of epilepsy patients. In none of these works, however, the performance of the seizure prediction statistics
is tested against a null hypothesis, an otherwise ubiquitous concept in science. In consequence, the evaluation
of the reported performance values is problematic. Here, we propose the technique of seizure time surrogates

  

Source: Andrzejak, Ralph Gregor - Departament de Tecnologia, Universitat Pompeu Fabra

 

Collections: Computer Technologies and Information Sciences