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Summary: REVIEW
A pharmacological analysis of mice with a targeted
disruption of the serotonin transporter
Meredith A. Fox & Anne M. Andrews &
Jens R. Wendland & Klaus-Peter Lesch &
Andrew Holmes & Dennis L. Murphy
Received: 12 April 2007 /Accepted: 28 June 2007 / Published online: 22 August 2007
# Springer-Verlag 2007
Abstract
Rationale Partial or complete ablation of serotonin trans-
porter (SERT) expression in mice leads to altered responses
to serotonin receptor agonists and other classes of drugs.
Objectives In the current report, we review and integrate
many of the major behavioral, physiological, and neuro-
chemical findings in the current literature regarding
pharmacological assessments made in SERT mutant mice.
Results The absence of normal responses to serotonin
reuptake inhibiting (SRI) antidepressants in SERT knockout
(-/-) mice demonstrates that actions on SERT are a critical
principle mechanism of action of members of this class of
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