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Two types of dopamine neuron distinctly convey positive and negative motivational signals
 

Summary: LETTERS
Two types of dopamine neuron distinctly convey
positive and negative motivational signals
Masayuki Matsumoto1
& Okihide Hikosaka1
Midbrain dopamine neurons are activated by reward or sensory
stimuli predicting reward14
. These excitatory responses increase
as the reward value increases5
. This response property has led to a
hypothesis that dopamine neurons encode value-related signals
and are inhibited by aversive events. Here we show that this is true
only for a subset of dopamine neurons. We recorded the activity of
dopamine neurons in monkeys (Macaca mulatta) during a
Pavlovian procedure with appetitive and aversive outcomes
(liquid rewards and airpuffs directed at the face, respectively).
We found that some dopamine neurons were excited by reward-
predicting stimuli and inhibited by airpuff-predicting stimuli, as
the value hypothesis predicts. However, a greater number of dopa-
mine neurons were excited by both of these stimuli, inconsistent

  

Source: Andrzejak, Ralph Gregor - Departament de Tecnologia, Universitat Pompeu Fabra

 

Collections: Computer Technologies and Information Sciences