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SPECIAL ISSUE PATTERNS & PHENOTYPES Temporal and Spatial Expression of FGF

Temporal and Spatial Expression of FGF
Ligands and Receptors During Xenopus
Robert Lea, Nancy Papalopulu, Enrique Amaya,* and Karel Dorey*
Fibroblast growth factor (FGF) signalling plays a major role during early vertebrate development. It is
involved in the specification of the mesoderm, control of morphogenetic movements, patterning of the
anterior-posterior axis, and neural induction. In mammals, 22 FGF ligands have been identified, which can
be grouped into seven subfamilies according to their sequence homology and function. We have cloned 17
fgf genes from Xenopus tropicalis and have analysed their temporal expression by RT-PCR and spatial
expression by whole mount in situ hybridisation at key developmental stages. It reveals the diverse
expression pattern of fgf genes during early embryonic development. Furthermore, our analysis shows the
transient nature of expression of several fgfs in a number of embryonic tissues. This study constitutes the
most comprehensive description of the temporal and spatial expression pattern of fgf ligands and receptors
during vertebrate development to date. Developmental Dynamics 238:14671479, 2009.
2009 Wiley-Liss, Inc.
Key words: Xenopus; otic vesicle; FGFR; FGF; iFGF; FHF
Accepted 31 January 2009
The mammalian Fibroblast Growth


Source: Amaya, Enrique - Healing Foundation Centre & Developmental Biology, Faculty of Life Sciences, University of Manchester


Collections: Biology and Medicine