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Constructive Episodic Simulation: Temporal Distance and Detail of Past and Future Events Modulate Hippocampal Engagement
 

Summary: Constructive Episodic Simulation: Temporal Distance and Detail of
Past and Future Events Modulate Hippocampal Engagement
Donna Rose Addis1,2
* and Daniel L. Schacter1,2
ABSTRACT: Behavioral, lesion and neuroimaging evidence show strik-
ing commonalities between remembering past events and imagining
future events. In a recent event-related fMRI study, we instructed partici-
pants to construct a past or future event in response to a cue. Once an
event was in mind, participants made a button press, then generated
details (elaboration) and rated them. The elaboration of past and future
events recruited a common neural network. However, regions within this
network may respond differentially to event characteristics, such as the
amount of detail generated and temporal distance, depending on whether
the event is in the past or future. To investigate this further, we con-
ducted parametric modulation analyses, with temporal distance and
detail as covariates, and focused on the medial temporal lobes and fron-
topolar cortex. The analysis of detail (independent of temporal distance)
showed that the left posterior hippocampus was responsive to the
amount of detail comprising both past and future events. In contrast, the
left anterior hippocampus responded differentially to the amount of

  

Source: Addis, Donna Rose - Department of Psychology, University of Auckland
Schacter, Daniel - Department of Psychology, Harvard University

 

Collections: Biology and Medicine