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Available online at www.sciencedirect.com Computers and Chemical Engineering 32 (2008) 356369

Summary: Available online at www.sciencedirect.com
Computers and Chemical Engineering 32 (2008) 356369
Identification of regulatory mechanisms of the
hepatic response to thermal injury
E. Yanga, T.J. Maguirea, M.L. Yarmusha,
F. Berthiaumeb, I.P. Androulakisa,
a Biomedical Engineering Department, Rutgers University, Piscataway, NJ, USA
b Center for Engineering in Medicine/Surgical Services, Massachusetts General Hospital,
Harvard Medical School and the Shriners Hospitals for Children, Boston, MA, USA
Received 30 October 2006; received in revised form 11 February 2007; accepted 13 February 2007
Available online 25 February 2007
The purpose of this paper is to evaluate the hypothesis that a systems biology approach can be developed such that a set of transcription
factors, relevant to burn-induced inflammatory response can be identified and modulated to control the host response. We explore a novel method
for identifying coherent and informative expression motifs and we subsequently determine conserved transcription factor binding sites for the
sub-sets of co-expressed genes. The responses are rationalized in the context of burn-induced inflammation and the putative transcription factors
are rationalized in the context of intervention targets for controlling gene expression.
2007 Published by Elsevier Ltd.
Keywords: Gene expression; Burn; Inflammation; Transcritpion factors
1. Introduction


Source: Androulakis, Ioannis (Yannis) - Biomedical Engineering Department & Department of Chemical and Biochemical Engineering, Rutgers University


Collections: Engineering; Biology and Medicine