Summary: Available online at www.sciencedirect.com
Computers and Chemical Engineering 32 (2008) 356­369
Identification of regulatory mechanisms of the
hepatic response to thermal injury
E. Yanga, T.J. Maguirea, M.L. Yarmusha,
F. Berthiaumeb, I.P. Androulakisa,
a Biomedical Engineering Department, Rutgers University, Piscataway, NJ, USA
b Center for Engineering in Medicine/Surgical Services, Massachusetts General Hospital,
Harvard Medical School and the Shriners Hospitals for Children, Boston, MA, USA
Received 30 October 2006; received in revised form 11 February 2007; accepted 13 February 2007
Available online 25 February 2007
Abstract
The purpose of this paper is to evaluate the hypothesis that a systems biology approach can be developed such that a set of transcription
factors, relevant to burn-induced inflammatory response can be identified and modulated to control the host response. We explore a novel method
for identifying coherent and informative expression motifs and we subsequently determine conserved transcription factor binding sites for the
sub-sets of co-expressed genes. The responses are rationalized in the context of burn-induced inflammation and the putative transcription factors
are rationalized in the context of intervention targets for controlling gene expression.
© 2007 Published by Elsevier Ltd.
Keywords: Gene expression; Burn; Inflammation; Transcritpion factors
1. Introduction

Source: Androulakis, Ioannis (Yannis) - Biomedical Engineering Department & Department of Chemical and Biochemical Engineering, Rutgers University

Collections: Engineering; Biology and Medicine