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Plasmodium Circumsporozoite Protein Promotes the Development of the

Summary: Plasmodium Circumsporozoite Protein
Promotes the Development of the
Liver Stages of the Parasite
Agam Prasad Singh,1,* Carlos A. Buscaglia,1 Qian Wang,1 Agata Levay,3 Daniel R. Nussenzweig,3
John R. Walker,4 Elizabeth A. Winzeler,4,5 Hodaka Fujii,1,2 Beatriz M.A. Fontoura,3,6 and Victor Nussenzweig1,6
1Department of Pathology
2NYU Cancer Institute
New York University School of Medicine, New York, NY 10016, USA
3Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
4Genomics Institute of the Novartis Research Foundation, San Diego, CA 92037, USA
5Department of Cell Biology, ICND202 The Scripps Research Institute La Jolla, CA 92037, USA
6These authors contributed equally to this work.
*Correspondence: singha05@med.nyu.edu
DOI 10.1016/j.cell.2007.09.013
The liver stages of malaria are clinically silent
but have a central role in the Plasmodium life
cycle. Liver stages of the parasite containing
thousands of merozoites grow inside hepato-
cytes for several days without triggering an in-


Source: Arnold, Jonathan - Nanoscale Science and Engineering Center & Department of Genetics, University of Georgia


Collections: Biotechnology