Summary: A Simple Algorithm for Detecting
Circular Permutations in Proteins
S. Uliel 1 , A. Fliess 1 , A. Amir 2y , R. Unger 1\Lambda
June 1999
1 Faculty of Life Sciences
2 Department of Computer Science and College of Computing, Georgia Tech
Bar­Ilan University
Ramat­Gan, 52900, Israel
\Lambda Corresponding author: ron@biocom1.ls.biu.ac.il
Tel: 972­3­5318124
Fax: 972­3­5351824
y Partially supported by NSF grant CCR­96­10170 and BSF grant 96­000509.

Abstract
Motivation: Circular permutation of a protein is a genetic operation in which part
of the C­terminal of the protein is moved to its N­terminal. Recently, it has been shown
that proteins that undergo engineered circular permutations generally maintain their three
dimensional structure and biological function. This observation raises the possibility that
circular permutation has been used by Nature during evolution. In this scenario a protein
underwent circular permutation into another proteins, thereafter both proteins further di­

Source: Amir, Amihood - Computer Science Department, Bar Ilan University

Collections: Mathematics