Home

About

Advanced Search

Browse by Discipline

Scientific Societies

E-print Alerts

Add E-prints

E-print Network
FAQHELPSITE MAPCONTACT US


  Advanced Search  

 
Rules for biological regulation based on error minimization
 

Summary: Rules for biological regulation based
on error minimization
Guy Shinar*
, Erez Dekel*
, Tsvi Tlusty
, and Uri Alon*
Departments of *Molecular Cell Biology and Physics of Complex Systems, Weizmann Institute of Science, Rehovot 76100, Israel
Edited by Michael S. Waterman, University of Southern California, Los Angeles, CA, and approved January 13, 2006 (received for review August 9, 2005)
The control of gene expression involves complex mechanisms that
show large variation in design. For example, genes can be turned
on either by the binding of an activator (positive control) or the
unbinding of a repressor (negative control). What determines the
choice of mode of control for each gene? This study proposes rules
for gene regulation based on the assumption that free regulatory
sites are exposed to nonspecific binding errors, whereas sites
bound to their cognate regulators are protected from errors.
Hence, the selected mechanisms keep the sites bound to their
designated regulators for most of the time, thus minimizing
fitness-reducing errors. This offers an explanation of the empiri-
cally demonstrated Savageau demand rule: Genes that are needed

  

Source: Alon, Uri - Departments of Molecular Cell Biology & Physics of Complex Systems, Weizmann Institute of Science
Tlusty, Tsvi - Department of Physics of Complex Systems, Weizmann Institute of Science

 

Collections: Biology and Medicine; Physics