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Divergent Roles of a Pair of Homologous Jumonji/ Zinc-FingerClass Transcription Factor Proteins

Summary: Divergent Roles of a Pair of Homologous Jumonji/
Zinc-Finger­Class Transcription Factor Proteins
in the Regulation of Arabidopsis Flowering Time
Bosl Noh,a,b,1 Seung-Hee Lee,a Hyun-Jin Kim,a Gibum Yi,a,b Eun-Ah Shin,a,b Mirha Lee,a Kyung-Ja Jung,a
Mark R. Doyle,c Richard M. Amasino,c and Yoo-Sun Noha,b,c,1
a Kumho Life and Environmental Science Laboratory, Puk-Gu, Kwangju 500-712, Korea
b Environmental Biotechnology National Core Research Center, Gyeongsang National University, Jinju 660-701, Korea
c Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin, Madison, Wisconsin 53706-1544
Flowering in Arabidopsis thaliana is controlled by multiple pathways, including the photoperiod pathway and the
FLOWERING LOCUS C (FLC)-dependent pathway. Here, we report that a pair of related jumonji-class transcription factors,
EARLY FLOWERING 6 (ELF6) and RELATIVE OF EARLY FLOWERING 6 (REF6), play divergent roles in the regulation of
Arabidopsis flowering. ELF6 acts as a repressor in the photoperiod pathway, whereas REF6, which has the highest similarity
to ELF6, is an FLC repressor. Ectopic expression studies and expression pattern analyses show that ELF6 and REF6 have
different cellular roles and are also regulated differentially despite their sequence similarities. Repression of FLC expression
by REF6 accompanies histone modifications in FLC chromatin, indicating that the transcriptional regulatory activity of this
class of proteins includes chromatin remodeling. This report demonstrates the in vivo functions of this class of proteins in
higher eukaryotes.
Flowering is a major developmental switch in plants and involves
a transition from vegetative to reproductive growth. Because


Source: Amasino, Richard M. - Department of Biochemistry, University of Wisconsin at Madison


Collections: Biology and Medicine