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letters to nature NATURE |VOL 404 |27 APRIL 2000 |www.nature.com 1007

Summary: letters to nature
NATURE |VOL 404 |27 APRIL 2000 |www.nature.com 1007
27. Jeanpierre, M. Human satellites 2 and 3. Ann. Genet. 37, 163±171 (1994).
28. Toyota, M. et al. Identi®cation of differentially methylated sequences in colorectal cancer by
methylated CpG island ampli®cation. Cancer Res. 59, 2307±2312 (1999).
29. Herman, J. G., Graff, J. R., Myohanen, S., Nelkin, B. D. & Baylin, S. B. Methylation-speci®c PCR: a
novel PCR assay for methylation status of CpG islands. Proc. Natl Acad. Sci. USA 93, 9821±9826
30. Cameron, E. E., Bachman, K. E., Myohanen, S., Herman, J. G. & Baylin, S. B. Synergy of demethylation
and histone deacetylase inhibition in the re- expression of genes silenced in cancer. Nature Genet. 21,
103±107 (1999).
Supplementary information is available from Nature's World-Wide Web site (http://
www.nature.com) or as paper copy from the London editorial of®ce of Nature.
We thank S. R. Lee and S. G. Rhee for sharing their expertise in HPLC analysis. We thank
T. Chan, M. Esteller, N. Watkins and other members of our laboratories for helpful
discussions. This work was supported by the Clayton Fund and by the National Institutes
of Health. K.E.S. is a Fellow of the American Cancer Society.
Correspondence and requests for materials should be addressed to K.E.S.
(e-mail: kornels@welchlink.welch.jhu.edu).


Source: Amann, Kurt - Molecular and Cellular Pharmacology Training Program & Department of Zoology, University of Wisconsin at Madison
Pollard, Thomas D.- Department of Molecular, Cellular and Developmental Biology, Yale University


Collections: Biology and Medicine