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Directed Evolution of a Cytochrome P450 Monooxygenase for Alkane Oxidation

Summary: Directed Evolution of a Cytochrome P450
Monooxygenase for Alkane Oxidation
Edgardo T. Farinas, Ulrich Schwaneberg, Anton Glieder, Frances H. Arnold*
Division of Chemistry and Chemical Engineering 210-41, California Institute of Technology, Pasadena, CA 91125, USA
Fax: (+1) 626-568-8743, e-mail: frances@cheme.caltech.edu
Received March 23, 2001; Accepted May 23, 2001
The term paraffin (from Latin parum affinis = slight
affinity) accurately reflects the nature of these com-
pounds: alkanes are notoriously inert, and activating
their C-H bonds presents a difficult chemical obsta-
cle. In fact, one of the great challenges of contempor-
ary catalysis is the controlled oxidation of hydrocar-
Processes for controlled, stereo- and
regioselective oxidation of hydrocarbon feed stocks
to more valuable and useful products such as alco-
hols, ketones, acids, and peroxides would have a ma-
jor impact on the chemical and pharmaceutical in-


Source: Arnold, Frances H. - Division of Chemistry and Chemical Engineering, California Institute of Technology


Collections: Chemistry; Biology and Medicine