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Genmab Shares Dive Sharply
on Zalutumumab Phase III Miss
By Cormac Sheridan
BioWorld Today Correspondent
Shares in Genmab A/S slid more than 20 percent Mon-
day on news that zalutumumab, an antibody-targeting epi-
dermal growth factor receptor (EGFR), failed to reach the
primary endpoint of a pivotal Phase III trial in head and
The Copenhagen, Denmark-based company reported
that patients who received the drug plus best supportive
care attained a median survival of 6.7 months, while those
on best supportive care alone attained a median overall
survival of 5.2 months. However, the result was not statis-
tically significant (p = 0.0648).
The drug did better on a secondary endpoint.
Patients in the drug treatment arm achieved a 61 per-